Which disorder is identified as an autosomal dominant condition characterized by brittle bones?

Which disorder is identified as an autosomal dominant condition characterized by brittle bones?

• A. Osteogenesis imperfecta
• B. Spina bifida
• C. Diplegia
• D. Paraplegia

Answer: (A)

Osteogenesis imperfecta is correctly identified as an autosomal dominant condition characterized by brittle bones. This disorder results from a genetic mutation that affects the production of collagen, an essential protein that provides structure and strength to bones. The impaired collagen synthesis leads to increased fragility of the bones, causing them to break easily, often without significant trauma. In contrast, spina bifida, diplegia, and paraplegia are related to different neurological or developmental conditions. Spina bifida involves a defect in the closure of the spine that can lead to varying degrees of physical impairments, but it does not specifically affect bone fragility in the same way osteogenesis imperfecta does. Diplegia and paraplegia refer to types of paralysis affecting muscle control and movement, rather than being a bone-related disorder. Therefore, osteogenesis imperfecta stands out as the only condition among the choices that specifically relates to brittle bones due to its genetic basis and effect on collagen.

Osteogenesis imperfecta is correctly identified as an autosomal dominant condition characterized by brittle bones. This disorder results from a genetic mutation that affects the production of collagen, an essential protein that provides structure and strength to bones. The impaired collagen synthesis leads to increased fragility of the bones, causing them to break easily, often without significant trauma.

In contrast, spina bifida, diplegia, and paraplegia are related to different neurological or developmental conditions. Spina bifida involves a defect in the closure of the spine that can lead to varying degrees of physical impairments, but it does not specifically affect bone fragility in the same way osteogenesis imperfecta does. Diplegia and paraplegia refer to types of paralysis affecting muscle control and movement, rather than being a bone-related disorder. Therefore, osteogenesis imperfecta stands out as the only condition among the choices that specifically relates to brittle bones due to its genetic basis and effect on collagen.